The staff of the University of Bat, led by Dr. Maysem Laabei and Dr. Jan Blagbro, discovered a compound that inhibits MRSA's superbacteria and makes it more vulnerable to antibiotics.
The new compound, polyamine, appears to destroy staphylococcus aureus, a bacteria that causes the deadly methicylline resistant infection of staphylococcus aureus, destroying the cellular membrane of the pathogen.
The combination was tested in vitro against 10 different antibiotic-resistant strains of S. aureus, including those known to be vancomicin resistant, a drug called the "last drug" for patients with MRSA infection. The new compound proved to be effective against all strains, thus halting the further growth of bacteria.
The study showed that, in addition to the direct destruction of S. aureus, polyamine can restore the sensitivity of strains of multi-drug-resistant bacteria to three important antibiotics — daptomicin, oxacillin, and vancomicin. As a result, antibiotics that have become ineffective over decades of overuse can eventually restore their ability to control serious infections.
"We are not quite sure why there is such a synergy between the compound and antibiotics, but we are seeking to explore it," explained Dr. Laabei, a researcher from the Department of Life Sciences at the University of Bata.
Polyamines are natural compounds that occur in most living organisms. A decade ago, they were thought to be essential for life, but scientists now know that they are absent from S. aureus and toxic to it. Researchers have already tried to exploit the unusual vulnerability of the pathogen to polio to suppress the growth of bacteria.
Scientists have now found that modified polio is much more effective in destroying antibiotics-resistant strains of gold staph, than even the most active natural polio.
Resistance to antibiotics poses a serious threat to human health worldwide, and S. aureus has become one of the deadliest known pathogens with multiple drug resistance.
A recent study on the impact of SCP on health in 2019 found that this pathogen is associated with a million deaths worldwide due to non-treated antibiotics.
S. aureus is found in 30 per cent of the world ' s population, and it is one of the most dangerous bacteria in the world. Until recently, MRSA was treated as a hospital problem, and the victims were mostly people with already weakened immune systems, but over the past 20 years there has been an increase in community-wide morbidity, even among healthy people.