A laser microscope has been created that explores living tissue using gas bubbles

A laser microscope has been created that explores living tissue using gas bubbles

Korean researchers at the Tegu Kenbuk Institute of Science and Technology have developed the world ' s first laser scanning microscopic technology, which allows for deep and detailed observation of biological tissues through gas bubbles, and is designed for research and medical centres.

As early as 2017, a group of researchers led by Professor DGIST Jin Ho Chang suggested that the micrometre gas bubbles that are typically observed when exposed to high-intensity ultrasound on the tissue could be used to improve the quality of the images obtained from laser scans.

In a paper published in Nature Photos, scientists have announced the successful development and testing of such an installation, the principle of operating the device is based on the fact that gas bubbles temporarily created by ultrasonic waves cause optical dispersion in the same direction as the spread of falling light, thereby increasing the depth of light penetration.

Scientists have developed ultrasonic technology to create a bubble layer in the right area with dense gas bubbles inside living tissue. The device can hold the formed gas bubbles throughout the scanning process. In this layer, there is no distortion in the direction of photon distribution, scientists point out.

A confocular fluorescent microscope is a device that selectively detects fluorescent signals generated in the light plane; it provides high-consensual images of microstructures such as cancer cells with high resolution; these microscopes are widely used in medicine and life science research.

The main problem with the microscope is that at depths of more than 100 μm, the focus of light is eroded by the diffusion of light occurring inside the tissue. This significantly limits the use and effectiveness of a conflictive fluorescent microscope. The new technology solves this problem by allowing you to look deeper and create clearer images.