Found an enzyme that "saves" cells from stress

Found an enzyme that "saves" cells from stress

Researchers at the Southwest University of Texas have shown that Fic's enzyme acts as a thermostat in controlling cell responses to stress, and scientists believe that discovery will help to develop new treatments for diseases characterized by uncontrolled cellular stress, such as cancer, metabolic syndrome, and neurodegenerative disorders.

As early as 2018, researchers had shown that flies constantly exposed to bright light, which damaged their eyes, were subjected to irreversible disturbances if they were removed from the Fic gene. However, the role of this enzyme in mammals was still unclear.

To answer this question, researchers modified the mouse genome by blocking the gene responsible for producing the Fic enzyme. In the first phase, the redacted animals were no different from normal mice from the same manure. Scientists did not feed animals for 14 hours, and then opened unrestricted access to food for two hours, thereby creating stress on the pancreas.

It turns out that animals with an enzyme deficit have shown a much higher response to stress than their brothers and sisters. Further research has shown that the molecular path, called the reaction of a deployed protein, which is activated when stress cells are unable to cope with the formation of new proteins, has been more activated in animals with a Fic deficit.

Researchers have drawn similar conclusions when mice were injected with a drug called cerulein, which affects the pancreatic gland, causing an increased release of digestive enzymes.

Researchers point out that uncontrolled cellular stress response and UPR play a role in the development of many diseases; if scientists can determine how a "spess thermostat" is designed, they can artificially manage it to treat cancer and neurodegenerative diseases.