Mutations in one RNA gene increase life expectancy

Mutations in one RNA gene increase life expectancy

Researchers at the Max Planck Institute of Ageing Biology in Keln have studied the effects of mutations in RNA on worm life expectancy, and a study has shown that worms live longer when certain RNAs are treated differently during RNA maturation. There are similar mutations in humans.

Researchers discovered in worms a gene called PUF60, which participates in the RNA splaysing and regulates life expectancy, and again, splashing is the cutting out of individual nucleotide sequences from RNA molecules and the compounding of sequences that remain in the mature molecule during the maturation of the RNA molecule.

Biologists have found that mutations in the PUF60 gene caused inaccurate splashing and retention in the intran molecule.

The genetic mutation has had a particularly strong impact on protein production, which is part of the MTOR signal route. It is an important sensor of food availability and serves as a control centre for cell metabolism, a mechanism that has long attracted the attention of scientists working on anti-age drugs.

Researchers point out that individual mutations in the PUF60 gene are also observed in humans; generally, patients suffer from a disorder of growth and development of the nervous system, and scientists have shown that a decrease in the activity of PUF60 in the artificial environment from human cells results in a decrease in the activity of the signal path mTOR.

Scientists believe that further research on this gene will help to develop anti-age therapy and treatment for diseases in people with natural disabilities in PUF60.