Scientists have defeated a stable anthrax without antibiotics

Scientists have defeated a stable anthrax without antibiotics

The spread of antibiotic resistance poses new threats, and researchers have presented in the American Chemical Society journal a method that allows for the removal of anthrax protection and immunity to combat infection.

Bacillus anthracis is a type of bacteria that can cause anthrax infection by exposure to spores when swallowed, inhaled or cut on the skin. Infection can lead to difficult breathing, skin ulcers, or even death. Scientists have developed antibiotics to treat the infection, but over time bacteria develop resistance to them.

In their work, scientists have explored the Ames strain, which is a particularly virulent version of Bacillus anthracis. Its secret is hidden in a poly-D-glutamine acid shell that acts as an invisible cloak, helping bacteria to avoid the human immune system. The protective shell is attached to bacteria with the help of the CapD enzyme.

Researchers have found that the additional introduction of this enzyme does not increase, but rather weakens protection. Scientists have reconstructed the enzyme and reinforced it with polyethylene glycol in order to keep the enzyme longer.

To further improve the effectiveness of the therapy, researchers modified the enzyme enriched by PES, connecting it with mice antibodies to anthrax. When tested on a mouse model, the design lasted longer than the previous version without a leaked antibodies, although it was less active.