Can Ageing Be Slowened?

Can Ageing Be Slowened?

Ageing is the progressive loss of the body's ability to sustain itself, which results in the functional decline of our cells and tissues. The distinctive signs of aging are genomic instability, loss of the homeostasis of proteins, disinfection of mitochondrium, disruption of the link between the cells and the body, and the depletion of stem cells.

But what's the reason for this? There are several factors that need to be considered. For starters, all cells are divided. That's how we're growing. Every time a cell divides, its DNA replicates.

In addition, every replication, a small portion of DNA is lost. However, our cells are adapted to this loss with a body meter. This is a repeated sequence of DNA at the end of the chromosomes. Their role is to provide excess DNA with a buffer that our cells can afford to lose. But once they end... they disappear!

The control of DNA replication is not in our hands... yet. However, we can control the most progressive factor of aging: free radicals. Free radicals are high-reactive oxygen molecules formed in our body through normal metabolic processes. Human beings need oxygen to breathe and perform multiple biochemical processes, while oxygen is chemically divided with energy, and we stay with oxygen molecules that lack electrons.

Examples of such free radicals are hydroxyl and usually formed in mitochondriums.

As you may recall from the school chemistry course, atoms that have no electrons will look for a partner to separate or take away the electron. It makes them jets because they want to mix with other elements. These free radicals react with our DNA, lipids and proteins and damage them by causing wear on our cells.

The formation of free radicals is normal, but unhealthy lifestyle habits, such as smoking and stress, can increase the rate of their education. The human body has ways of self-repair, but with time, the effectiveness of self-repair decreases. This, combined with the increased production of free radicals, physically wears over the body, and is already getting old.

Once we learned the two main causes of aging, we tried to slow it down by acting on them. There are several ways to do that.

Maintenance of the bodymer

After each DNA replication cycle, the telomers abbreviate. When the body is almost at the end, the cell replication cycle stops, and replicative ageing occurs. This term is used to describe the stage where the cells stop trying to grow. If we could find a way to make the telomers longer, we could find a way to make the cells live longer.

This is the enzyme of the body-merase enzyme which is present in some stem cells and which can continue to add repeated DNA sequences to the body-measures and delay aging. The stem cells have a special ability to produce the body-merase because they keep the body-measurers for future generations. However, the activity of the body-merase is strictly controlled. The incorrect activity of the body-merase can cause genetic instability and even disease, because uncontrolled changes in DNA can have a serious effect on the body.

Using stem cell treatments and genetic modifications, scientists try to manipulate the bodymerase so that it can dance under their cloaks, controlling how and when the thermometers extend, you can delay cell death and make them reproduce longer.

However, it's not easy for everyone to change their DNA, and it's gonna take time to achieve this technological theory. Isn't there something simpler, like a pill against aging?

Anti-age drugs

Recent studies have shown that some synthetic drugs contain chemicals that can delay aging, which activate enzymes that give more energy to our cells or stimulate the body to better self-rehabilitate and combat free radicals.

Consider, for example, a known drug of aspirin, which is used to relieve headache pain and to prevent clot formation, later studies have shown that it also prevents the formation of nitrogen oxide, a free radical that destroys the cell, and increases the activity of the bodymerase.

Metformin, a drug well known to diabetics, not only helps cells to become more sensitive to insulin, it activates adenosinmonophosphate-activated proteinkinase, an enzyme that plays an important role in many cellular pathways so that it can control metabolism in the body.

People use adenosinthosphate as an energy currency in their cells. When an ATF ends in a cell, the AMPK is activated. This enzyme includes ways that give the cells an energy boost because it increases glucose uptake and fatty acid splits. The energy surplus is directed to cell recovery and survival. The AMPK activation also suppresses other energy-intensive processes that are not needed at the moment, for example, lipid synthesis.

But just as some people don't like DNA modification, others don't want to take medication for the rest of their lives, so let's move on to other ways to delay aging.

Restriction of food calories

The caloric limit deprives the body of nutrients, but not to the extent that you become malnourished. This intervention slows down age changes and delays age diseases. Its mechanism is similar to that of metformin when the body enters survival mode. The key regulator in this approach is also APPC.

Low-calorie diet, i.e. glucose hunger, activates APPC. This food stress encourages APPC to activate cell survival pathways while suspending non-core pathways.

Low-calibre diets = less food consumed = less metabolic processes needed to split this food. If human metabolism decreases, oxygen splits in biochemical processes. Thus, calorie limitations also reduce the formation of free radicals, thus reducing the oxidative stress of cells. However, not everyone is a fan of self-smoke, especially as a long-term lifestyle.

Physical exercise

It is well known that exercise has an anti-age effect and improves health, and they struggle with several signs of aging.

Physical exercise strengthens muscles and resilience, which slows the likelihood of age-related diseases such as diabetes and osteoporosis.

Physical exercise requires cells to consume more energy, so you probably know what's activated to ensure it.

In addition, long-term exercise affects the activity of the bodymerase, so it can increase the length of the bodymera; it also activates the proteins that restore DNA, which significantly reduces mutations and DNA damage.

Physical exercise

Stress reduction

Stress

People with chronic stress are rapidly ageing. People with stress are prone to hyperimmune reactions when immune cells release pro-inflammatory cytokins. These molecules increase oxidation stress in the mitochondriums of other cells. The production of free radicals is increasing, causing damage to cells, and people with long-term stress are also more likely to get abbreviated. Moreover, one study has shown that in people with mood disorders, the length of the bodymer is shorter. Thus, stress makes the cells faster to reach the age stage. Too much stress even makes people predisposed to age-related diseases.

By scaring or avoiding stress, we reduce its harmful effects due to aging and increase life expectancy. Physical exercise is another fine way to cope with stress associated with cell ageing.

Regular sleep also helps to cope with stress and gives the body time to rest and recover. People with sleep problems are more likely to suffer from stress disorders than their sleeping colleagues. One study found that people with sleep problems have higher levels of ROS in the cornea, which contributes to faster eye ageing. In other words, it is time to remove the phone for the night.

Conclusion

It is not surprising that experts around the world pay great attention to healthy, balanced lifestyles, proper nutrition, and physical exercise, and there are many cyclic changes with age, but there are ways to combat them.

Our genes.