Scientists use mathematical simulations for controlled assembly of two-dimensional bacterial systems with proper functions.
Biologists from the Massachusetts Institute of Technology used mathematical simulations to manage gene-modified bacteria in the intestine stick . They managed to program bacterial systems to become arbitrary two-dimensional structures with appropriate properties.
Researchers have created a set of bioengineering tools to control the properties of intercellular adgesia of mobile bacterial cells. Genetically modified bacteria grow certain molecules on their cell walls, which act as interface locks for suitable cell partners.
As in the LEGO designer, only cells with overlapping molecules can be connected, explained by scientists. When two cellular populations with the corresponding adgesia molecules come into contact, they form a visible complete boundary, the position and shape of which are determined by the initial planting positions and cell concentrations.
Using computer simulations, scientists calculate the growth and spread of colonies of different bacteria to create the necessary flat structures at the site.
In their research, scientists have shown how controlled growth can produce flat living surfaces that include channels for the transport of liquids, and researchers believe that development will be useful for creating biosensors that are sensitive to various external irritators.
Biologists will continue to investigate controlled living systems, and in future experiments they want to move towards three-dimensional structures and systems that produce different chemicals at certain points.