Opening an amazingly powerful and unaddictive new painkiller

Opening an amazingly powerful and unaddictive new painkiller

Scientists have studied a compound called BNOCPA in several laboratory models. It has proved to be a powerful analgesic. Another advantage is that it is not addictive. This new non-addictive analgesic can be a valuable alternative to opioids, such as morphine and oxycodone.

Many of these drugs operate by interacting with proteins on the surface of cells that activate adaptive molecules called G proteins. However, there may be problems because the activation of some G proteins can lead to other cellular effects, such as sedative effects, bridicardia, hypotension or respiratory oppression. In short, many analgesics often cause unwanted side effects. Opioid drugs such as morphine and oxycodone can also cause addiction. These compounds become very dangerous when overdosed.

The aim of many specialized researchers is, therefore, to identify new compounds that can have a powerful effect on pain while avoiding side effects and addiction problems, one of which has been known in recent months: benzyloxy-cyclopentylene.

Based on an analysis conducted by a group led by the University of Warwick, the compound has selective effects. It activates only one type of G protein. As a result, it will have far fewer potential side effects. By testing a drug in model systems such as frog heart, rat brain, and human cells, researchers also found that beyond being a powerful painkiller, BNOCPA is not addictive.

"," explains Bruno Frangelli, a professor at the University of Geneva who led the work. "," adds Dr. Mark Wall, co-author of the study.

Note that this compound has not yet been tested in clinical trials, so we still have a long way to go before we can rely on it one day, but the results seem very promising.