The main study on Alzheimer's disease was called fabricated

The main study on Alzheimer's disease was called fabricated

The investigation found that Sylvain Lesne, the author of the 2006 study, had manipulated images several times during his work.

This article refers to more than 2,200 scientific works, describing protein Aβ*56, which is proposed to be used as a target to combat Alzheimer's disease.

Aβ*56 is beta-amyloid; beta-amyloids are proteins that accumulate in the brain; this process is associated with the development of Alzheimer's disease.

Matthew Schrag, a neuroscientist from Vanderbilt University, first reported his concerns about work in January 2022. Science asked two image analysts to look at Lesne's published work. They confirmed their concerns.

The experts identified a total of 20 suspicious works of which Lesne was the author, 10 of which involved protein Aβ*56.

Elizabeth Bick, a forensic image expert, believes that the images from the study in which the mice were injected beta-amyloid into the brain appear to have been modified to "be better suited to the hypothesis".

The analysis of many of the underlying data raised and the authors ' survey showed that the images were edited, including changing parts of them.